Legal

Xeomin: Copyright 2026 Merz North America, Inc. All rights reserved. MERZ AESTHETICS, XEOMIN, XTRACT TECHNOLOGY, and the XPERIENCE+ logo are registered trademarks of Merz Pharma GmbH & Co. KGaA in the U.S. All other marks are the property of their respective owners. US-XEA-2600018

XEOMIN^® (incobotulinumtoxinA) IMPORTANT CONSUMER SAFETY INFORMATION

Read the Medication Guide before you start receiving XEOMIN(Zeo-min) and each time XEOMIN is given to you as there may be new information. The risk information provided here is not comprehensive.

To learn more:

Talk to your health care provider or pharmacist
Visit www.xeominaesthetic.com to obtain the Full Prescribing Information and Medication Guide
Call 1-866-862-1211

Uses: XEOMIN is aprescription medicine that is injected into muscles and used to improve thelook of moderate to severe upper facial lines (frown lines, forehead lines, andcrow’s feet) in adults for a short period of time (temporary). Please see additional Important Safety Information below and Full Prescribing Information and Medication Guide at XeominAesthetic.com.

Warnings: XEOMIN may cause serious side effects that can be life threatening. Call your doctor or get medical help right away if you have any of these problems anytime (hours to weeks) after treatment with XEOMIN:

‍Problems with swallowing, speaking, or breathing can happen within hours to weeks after an injection of XEOMIN if the muscles that you use to breathe and swallow become weak. Death can happen as a complication if you have severe problems with swallowing or breathing after treatment with XEOMIN.
- People with certain breathing problems may need to use muscles in their neck to help them breathe and may be at greater risk for serious breathing problems with XEOMIN.
- Swallowing problems may last for several months, and during that time you may need a feeding tube to receive food and water. If swallowing problems are severe, food or liquids may go into your lungs. People who already have swallowing or breathing problems before receiving XEOMIN have the highest risk of getting these problems.
Spread of toxin effects. In some cases, the effect of botulinum toxin may affect areas of the body away from the injection site and cause symptoms of a serious condition called botulism. The symptoms of botulism include: loss of strength and muscle weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, trouble swallowing.

These symptoms can happen hours to weeks after you receive an injection of XEOMIN. These problems could make it unsafe for you to drive a car or do other dangerous activities.

Do not use XEOMIN if you are allergic to XEOMIN or any of theingredients in XEOMIN (see the end of this Guide for a list of ingredients inXEOMIN), had an allergic reaction to any other botulinum toxin products such asrimabotulinumtoxinB (MYOBLOC^®), onabotulinumtoxinA (BOTOX^®,BOTOX^® COSMETIC), or abobotulinumtoxinA (DYSPORT^®) or have a skin infection at the planned injection site.

Before receiving XEOMIN, tell your doctor about all of your medical conditions, including if you:

have a disease that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou Gehrig’s disease], myasthenia gravis or Lambert-Eaton syndrome)
have had any side effect from any other botulinum toxin in the past
have a breathing problem such as asthma or emphysema
have a history of swallowing problems or inhaling food or fluid into your lungs (aspiration)
have bleeding problems
have drooping eyelids
have plans to have surgery
have had surgery on your face
are pregnant or plan to become pregnant. It is not known if XEOMIN can harm your unborn baby.
are breastfeeding or plan to breastfeed. It is not known if XEOMIN passes into breast milk.

Tell your doctor about all of the medicines you take, including prescription and over-the-counter medicines,vitamins and herbal supplements. Talk to your doctor before you takeany new medicines after you receive XEOMIN.

Using XEOMIN with certain other medicines may cause seriousside effects. Do not start any new medicines until you have told your doctor that you have received XEOMIN in the past. Especially tell your doctor if you

have received any other botulinum toxin product in the last four months
have received injections of botulinum toxin such as rimabotulinumtoxinB (MYOBLOC®), onabotulinumtoxinA (BOTOX®, BOTOX®COSMETIC) and abobotulinumtoxinA (DYSPORT®) in the past. Be sure your doctor knows exactly which product you received. The dose of XEOMIN may be different from other botulinum toxin products that you have received.
have recently received an antibiotic by injection
take muscle relaxants
take an allergy or cold medicine
take a sleep medicine

Ask your doctor if you are not sure if your medicine is one that is listed above. Know the medicines you take. Keep a list of your medicines with you to show your doctor and pharmacist each time you get a new medicine.

Possible Side Effects

XEOMIN can cause serious side effects that can be life threatening including allergic reactions. Symptoms of an allergic reaction to XEOMIN may include: itching,rash, redness, swelling, wheezing, asthma symptoms, or dizziness or feeling faint. Tell your doctor or get medical help right away if you get wheezing orasthma symptoms, or if you get dizzy or faint. See “Warnings.”

The most common side effect of XEOMIN in people with upper facial lines include:

injection site bruising

These are not all the possible side effects of XEOMIN. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or call 1-800-FDA-1088.

General information about the safe and effective use of XEOMIN

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. You can ask your pharmacist or doctor for information about XEOMIN that is written for health professionals.

Active Ingredient: botulinum toxin type A

Inactive Ingredients: human albumin and sucrose

Radiesse: ©2026 Merz North America, Inc. All rights reserved. MAX MERZ AESTHETICS EXCHANGE, MERZ AESTHETICS, and the MERZ AESTHETICS Logo are registered trademarks and XPERIENCE+ is a pending trademark of Merz Pharma GmbH & Co. KGaA in the U.S. RADIESSE and the R Logo are registered trademarks of Merz North America, Inc. in the U.S. All other trademarks are the property of their respective owners. US-RAD-2600057.

Belotero: Copyright © 2024 Merz North America, Inc. All rights reserved. MERZ AESTHETICS, BELOTERO, and BELOTERO BALANCE are registered trademarks of Merz Pharma GmbH & Co. KGaA in the U.S. NEOCUTIS is a registered trademark of Anteis S.A. in the U.S. RADIESSE is a registered trademark of Merz North America, Inc. in the U.S. ULTHERAPY is a registered trademark of Ulthera, Inc. in the U.S. US-BEL-2300064

Ultherapy: The ULTHERA® System is U.S. FDA-cleared to lift the eyebrow, the skin on the neck and under the chin as well as to improve lines and wrinkles on the décolleté. The most common side effects reported in clinical trials were redness, swelling, pain and transient nerve effects. Reported adverse events from post-marketing surveillance are available in the Instructions for Use (IFU). Please see the IFU for product and safety information, including a full list of these events at Ultherapy.com/IFU.

© 2025 Merz North America, Inc. All rights reserved. MERZ AESTHETICS is a registered trademark of Merz Pharma GmbH & Co. KGaA in the U.S. ULTHERAPY, ULTHERAPY PRIME, the SQUIGGLE logo, and the U ULTHERAPY logo are registered trademarks, and THE LIFT YOU CAN SEE and ULTHERAPY PRIME THELIFT YOU CAN SEE are pending trademarks, of Ulthera, Inc. in the U.S.

US-ULT-2400131

Resilielle: RESILIÉLLE COSMETICS LLC. Manufactured in the United States

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